Efficacy and safety of fecal microbiota transplantation by washed preparation in patients with moderate to severely active ulcerative colitis.

ABSTRACT:

Objective

We aimed to evaluate the short-term efficacy and safety of fecal microbiota transplantation (FMT) by washed preparation for moderate to severely active UC.

Methods

An open-label prospective trial was conducted in an inflammatory bowel disease (IBD) tertiary referral center from April 2016 to March 2018. Patients with moderate to severely active UC were randomly assigned to undergo FMT thrice on day 1, 3 and 5 by nasojejunal tube (NJT) or transendoscopic enteral tubing (TET). The primary end-point was a clinical response at week 2 post-FMT. The secondary end-points were clinical and endoscopic remission at week 12 post-FMT, safety and disease progression.

Results

Of the nine patients included, 77.8% (7/9) achieved a clinical response at week 2. And 55.6% (5/9

SUBMITTER: Chen M 

PROVIDER: S-EPMC7756426 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature