Influence of Ligand and Nuclearity on the Cytotoxicity of Cyclometallated C^N^C Platinum(II) Complexes.

ABSTRACT: A series of cyclometallated mono- and di-nuclear platinum(II) complexes and the parent organic ligand, 2,6-diphenylpyridine 1 (HC^N^CH), have been synthesized and characterized. This library of compounds includes [(C^N^C)Pt^II (L)] (L=dimethylsulfoxide (DMSO) 2 and triphenylphosphine (PPh₃ ) 3) and [((C^N^C)Pt^II )₂ (L')] (where L'=N-heterocycles (pyrazine (pyr) 4, 4,4'-bipyridine (4,4'-bipy) 5 or diphosphine (1,4-bis(diphenylphosphino)butane (dppb) 6). Their cytotoxicity was assessed against four cancerous cell lines and one normal cell line, with results highlighting significantly increased antiproliferative activity for the dinuclear complexes (4-6), when compared to the mononucleated species (2 and 3). Complex 6 is the most promising candidate,

SUBMITTER: Kergreis A 

PROVIDER: S-EPMC7756510 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature