Blood Metal Levels and Amyotrophic Lateral Sclerosis Risk: A Prospective Cohort.

ABSTRACT:

Objective

Metals have been suggested as a risk factor for amyotrophic lateral sclerosis (ALS), but only retrospective studies are available to date. We compared metal levels in prospectively collected blood samples from ALS patients and controls, to explore whether metals are associated with ALS mortality.

Methods

A nested ALS case-control study was conducted within the prospective EPIC (European Prospective Investigation into Cancer and Nutrition) cohort. Cases were identified through death certificates. We analyzed metal levels in erythrocyte samples obtained at recruitment, as a biomarker for metal exposure from any source. Arsenic, cadmium, copper, lead, manganese, mercury, selenium, and zinc concentrations were measured by inductively coupled plasma-mass spectrometry. T

SUBMITTER: Peters S 

PROVIDER: S-EPMC7756568 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature