Midlife Leukocyte Telomere Length as an Indicator for Handgrip Strength in Late Life.

ABSTRACT:

Background

Telomere attrition has been proposed as a hallmark of aging. We previously reported on the association between blood leukocyte telomere length (LTL) at midlife and risk of chronic diseases and mortality.

Methods

In this study, we investigated the effect of midlife LTL and genetic proxies on 5 markers of aging outcomes, namely handgrip strength, timed up-and-go (TUG), Singapore-modified Mini-Mental State Examination (SM-MMSE) scores, anxiety, and depression indices, measured after a median 20-year follow-up in the Singapore Chinese Health Study (N = 9581).

Results

We observed a significant association between midlife LTL and handgrip strength later in life (p = .004, padjust = .020), as well as a nominal significant association between midlife LTL and TUG la

SUBMITTER: Chang X 

PROVIDER: S-EPMC7756687 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature