Genes Related to Education Predict Frailty Among Older Adults in the United States.

ABSTRACT:

Objective

This article expands on research that links education and frailty among older adults by considering the role of genes associated with education.

Method

Data come from a sample of 7,064 non-Hispanic, white adults participating in the 2004-2012 waves of the Health and Retirement Study. Frailty was measured with two indices: (a) The Frailty Index which corresponds to a deficit accumulation model; and (b) The Paulson-Lichtenberg Frailty Index which corresponds to the biological syndrome/phenotype model. Genes associated with education were quantified using an additive polygenic score. Associations between the polygenic score and frailty indices were tested using a series of multilevel models, controlling for multiple observations for participants across waves.

Resul

SUBMITTER: Huibregtse BM 

PROVIDER: S-EPMC7756716 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature