Genotoxicity as a toxicologically relevant endpoint to inform risk assessment: A case study with ethylene oxide.

ABSTRACT: The purpose of the present investigation is to analyze the in vivo genotoxicity dose-response data of ethylene oxide (EO) and the applicability of the derived point-of-departure (PoD) values when estimating permitted daily exposure (PDE) values. A total of 40 data sets were identified from the literature, and benchmark dose analyses were conducted using PROAST software to identify a PoD value. Studies employing the inhalation route of exposure and assessing gene or chromosomal mutations and chromosomal damage in various tissues were considered the most relevant for assessing risk from EO, since these effects are likely to contribute to adverse health consequences in exposed individuals. The PoD estimates were screened for precision and the values were divided by data-derived adjustment fac

SUBMITTER: Gollapudi BB 

PROVIDER: S-EPMC7756744 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature