Development of a Reduced-Volume Acute Lethality Toxicity Test for Hyalella azteca.

ABSTRACT: Effects-directed analysis (EDA) is used to identify the principal toxic components within a complex mixture using iterative steps of chemical fractionation guided by bioassay results. Bioassay selection can be limited in EDA because of the volume requirements for many standardized test methods, and therefore, a reduced-volume acute toxicity test that also provides whole-organism responses is beneficial. To address this need, a static, 7-d, water-only, reduced-volume method (50 mL, 10 organisms) was developed for Hyalella azteca that substantially decreases the volume requirements of standard-volume acute test exposures (200-500 mL of test solution, 15-20 organisms) while maintaining water quality and meeting control survival criteria. Standard- and reduced-volume methods were compared by c

SUBMITTER: Rodrigues MR 

PROVIDER: S-EPMC7756806 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature