Neuropeptide Y nerve paracrine regulation of prostate cancer oncogenesis and therapy resistance.

ABSTRACT:

Background

Nerves are key factors in prostate cancer (PCa) progression. Here, we propose that neuropeptide Y (NPY) nerves are key regulators of cancer-nerve interaction.

Methods

We used in vitro models for NPY inhibition studies and subsequent metabolomics, apoptotic and migration assays, and nuclear transcription factor-κB (NF-κB) translocation studies. Human naïve and radiated PCa tissues were used for NPY nerve density biomarker studies. Tissues derived from a Botox denervation clinical trial were used to corroborate metabolomic changes in humans.

Results

Cancer cells increase NPY positive nerves in vitro and in preneoplastic human tissues. NPY-specific inhibition resulted in increased cancer apoptosis, decreased motility, and energetic metabolic pathway changes. A

SUBMITTER: Ding Y 

PROVIDER: S-EPMC7756863 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature