Intestinal permeability in human nonalcoholic fatty liver disease: A systematic review and meta-analysis.

ABSTRACT:

Background

The gut-liver axis is considered to play a critical role in the development and progression of nonalcoholic fatty liver disease (NAFLD). The integrity of the epithelial barrier is crucial to protect the liver against the invasion of microbial products from the gut, although its exact role in NAFLD onset and progression is not clear.

Methods

We performed a systematic review and meta-analysis of studies that addressed the intestinal permeability (IP) in association with NAFLD presence or severity as defined by the presence of nonalcoholic steatohepatitis (NASH) and the degree of steatosis, hepatic inflammation or fibrosis. A total of 14 studies were eligible for inclusion.

Results

Studies investigating IP in adult (n = 6) and paediatric (n = 8) NAFLD showed s

SUBMITTER: De Munck TJI 

PROVIDER: S-EPMC7756870 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature