Suzuki-Miyaura Cross-Coupling of Bromotryptophan Derivatives at Ambient Temperature.

ABSTRACT: Mild reaction conditions are highly desirable for bio-orthogonal side chain derivatizations of amino acids, peptides or proteins due to the sensitivity of these substrates. Transition metal catalysed cross-couplings such as Suzuki-Miyaura reactions are highly versatile, but usually require unfavourable reaction conditions, in particular, when applied with aryl bromides. Ligand-free solvent-stabilised Pd-nanoparticles represent an efficient and sustainable alternative to conventional phosphine-based catalysts, because the cross-coupling can be performed at considerably lower temperature. We report on the application of such a highly reactive heterogeneous catalyst for the Suzuki-Miyaura cross-coupling of brominated tryptophan derivatives. The solvent-stabilised Pd-nanoparticles are even mor

SUBMITTER: Dachwitz S 

PROVIDER: S-EPMC7756874 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature