Ontology highlight
ABSTRACT:
SUBMITTER: Diao P
PROVIDER: S-EPMC7756930 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Diao Pan P Wang Xiaojing X Jia Fangping F Kimura Takefumi T Hu Xiao X Shirotori Saki S Nakamura Ibuki I Sato Yoshiko Y Nakayama Jun J Moriya Kyoji K Koike Kazuhiko K Gonzalez Frank J FJ Aoyama Toshifumi T Tanaka Naoki N
The Journal of nutritional biochemistry 20200703
Previous studies suggested that high consumption of saturated fatty acid (SFA) is a risk factor for liver cancer. However, it remains unclear how dietary SFA affects liver tumorigenesis. This study aimed to investigate the impact of a SFA-rich diet on hepatic tumorigenesis using hepatitis C virus core gene transgenic (HCVcpTg) mice that spontaneously developed hepatic steatosis and tumors with aging. Male HCVcpTg mice were treated for 15 months with a purified control diet or SFA-rich diet prepa ...[more]