Gestational lipid profile as an early marker of metabolic syndrome in later life: a population-based prospective cohort study.

ABSTRACT:

Background

In pregnancy lipid levels increase with gestation resembling an atherogenic lipid profile. Currently it is unclear whether gestational lipid levels are associated with an adverse cardiovascular risk profile later in life. The aim of this study is to assess the association between gestational lipid levels and lipid levels and prevalence of the metabolic syndrome (MS) six years after pregnancy.

Methods

In plasma of 3510 women from the Generation R Study; a prospective population-based cohort, we measured lipid levels (total cholesterol, triglycerides and high-density lipoprotein cholesterol [HDL-c]), and low-density lipoprotein cholesterol (LDL-c), remnant cholesterol and non-HDL-c were calculated in early pregnancy (median 13.2 weeks, 90% range [10.5 to 17.1]) and

SUBMITTER: Adank MC 

PROVIDER: S-EPMC7756942 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature