Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila.

ABSTRACT: Hunger drives food-seeking behaviour and controls adaptation of organisms to nutrient availability and energy stores. Lipids constitute an essential source of energy in the cell that can be mobilised during fasting by autophagy. Selective degradation of proteins by autophagy is made possible essentially by the presence of LIR and KFERQ-like motifs. Using in silico screening of Drosophila proteins that contain KFERQ-like motifs, we identified and characterized the adaptor protein Arouser, which functions to regulate fat storage and mobilisation and is essential during periods of food deprivation. We show that hypomorphic arouser mutants are not satiated, are more sensitive to food deprivation, and are more aggressive, suggesting an essential role for Arouser in the coordinatio

SUBMITTER: Jacomin AC 

PROVIDER: S-EPMC7756965 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature