The Beneficial Effects of Apical Sodium-Dependent Bile Acid Transporter Inactivation Depend on Dietary Fat Composition.

ABSTRACT:

Scope

The apical sodium-dependent bile acid transporter (ASBT, SLC10A2) is important in the enterohepatic cycling of bile acids and thereby in the intestinal absorption of lipids. ASBT inhibition has been shown to improve aspects of the metabolic syndrome, but the underlying mechanisms have remained unclear. Here, the effect of ASBT inhibition on the uptake of specific fatty acids and its consequences for diet-induced obesity and non-alcoholic fatty liver disease (NAFLD) are investigated.

Methods

Intestinal fat absorption is determined in mice receiving an ASBT inhibitor and in Asbt^-/- mice. Metabolic disease development is determined in Asbt^-/- mice receiving a low-fat control diet (LFD) or high-fat diet (HFD) rich in saturated fatty acids (SFAs) or PU

SUBMITTER: van de Peppel IP 

PROVIDER: S-EPMC7757219 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature