Drug-Target Interaction Network Analysis of Gene-Phenotype Connectivity Maintained by Genistein.

ABSTRACT: Genistein is a type of isoflavone, which has been widely described as an antitumor agent in many cancers. The present study aimed to provide information on the mechanisms of genistein's activity and thus enable a wider range of targeted therapies in hepatitis B virus (HBV)-related liver cancer. We searched the DrugBank database for direct targets of genistein, which were then analyzed through the STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) database to predict their secondary protein targets. Thirteen primary protein targets of genistein and 209 secondary protein targets-associated genes were identified. The data were integrated into the network of protein targets-associated genes and visualized with the Cytoscape software. We further carried out GO (Gene Ontology)

SUBMITTER: Li B 

PROVIDER: S-EPMC7757588 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature