Characterization of Laminins in Healthy Human Aortic Valves and a Modified Decellularized Rat Scaffold.

ABSTRACT: Aortic valve stenosis is one of the most common cardiovascular diseases in western countries and can only be treated by replacement with a prosthetic valve. Tissue engineering is an emerging and promising treatment option, but in-depth knowledge about the microstructure of native heart valves is lacking, making the development of tissue-engineered heart valves challenging. Specifically, the basement membrane (BM) of heart valves remains incompletely characterized, and decellularization protocols that preserve BM components are necessary to advance the field. This study aims to characterize laminin isoforms expressed in healthy human aortic valves and establish a small animal decellularized aortic valve scaffold for future studies of the BM in tissue engineering. Laminin isoforms were asses

SUBMITTER: Granath C 

PROVIDER: S-EPMC7757704 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature