Ageing hallmarks exhibit organ-specific temporal signatures.

ABSTRACT: Ageing is the single greatest cause of disease and death worldwide, and understanding the associated processes could vastly improve quality of life. Although major categories of ageing damage have been identified-such as altered intercellular communication, loss of proteostasis and eroded mitochondrial function¹-these deleterious processes interact with extraordinary complexity within and between organs, and a comprehensive, whole-organism analysis of ageing dynamics has been lacking. Here we performed bulk RNA sequencing of 17 organs and plasma proteomics at 10 ages across the lifespan of Mus musculus, and integrated these findings with data from the accompanying Tabula Muris Senis²-or 'Mouse Ageing Cell Atlas'-which follows on from the original Tabula Muris³

SUBMITTER: Schaum N 

PROVIDER: S-EPMC7757734 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature