Metabolic syndrome and the incidence of knee osteoarthritis: A meta-analysis of prospective cohort studies.

ABSTRACT:

Background

Cross-sectional studies suggest an association between metabolic syndrome (MetS) and knee osteoarthritis (KOA). We performed a meta-analysis to evaluate whether MetS is an independent risk factor for KOA.

Methods

Prospective cohort studies evaluating the association between MetS and KOA in general population were retrieved from PubMed and Embase. Only studies with multivariate analyses were included. Data were pooled with a random-effect model, which is considered to incorporate heterogeneity among the included studies.

Results

Five studies including 94,965 participants were included, with 18,990 people with MetS (20.0%). With a mean follow-up duration of 14.5 years, 2,447 KOA cases occurred. Pooled results showed that MetS was not significant associated wi

SUBMITTER: Nie D 

PROVIDER: S-EPMC7757818 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature