Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer.

ABSTRACT: Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectional, two-sample Mendelian randomization analysis to investigate the relationship between levels of three blood lipids (low-density lipoprotein [LDL] and high-density lipoprotein [HDL] cholesterol, and triglycerides) and endometrial cancer risk. Genetic variants associated with each of these blood lipid levels (P < 5 × 10^-8 ) were identified as instrumental variables, and assessed using genome-wide association study data from the Endometrial Cancer Association Consor

SUBMITTER: Kho PF 

PROVIDER: S-EPMC7757859 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature