Effects of lipid composition on photothermal optical coherence tomography signals.

ABSTRACT: Photothermal optical coherence tomography (PT-OCT) has the promise to offer structural images coregistered with chemical composition information, which can offer a significant impact in early detection of diseases such as atherosclerosis. We take the first step in understanding the relation between PT-OCT signals and the endogenous tissue composition by considering the interplay between the opto-thermo-physical properties of tissue as a function of its lipid composition and the ensuing effects on the PT-OCT signals. Multiparameter theoretical estimates for PT-OCT signal as a function of composition in a two-component lipid-water model are derived and discussed. Experimental data from various concentrations of lipid in the form of droplets and injections under bovine cardiac muscle align wi

SUBMITTER: Salimi M 

PROVIDER: S-EPMC7757902 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature