Synthesis, Molecular Docking and Cytotoxic Activity Evaluation of Organometallic Thiolated Gold(I) Complexes.

ABSTRACT: The complex [(PhCH₂NC)AuCl], 1, was prepared by the reaction of [(Me₂S)AuCl], A, with an equimolar amount of benzyl isocyanide (PhCH₂NC) ligand. Through a salt metathesis reaction, the chloride ligand in 1 was replaced by potassium benzothiazole-2-thiolate (Kbt) and potassium benzoimidazole-2-thiolate (Kbi) to afford complexes (PhCH₂NC)Au(κ¹-S-bt)], 2a and (PhCH₂NC)Au(κ¹-S-bi)], 2b, respectively, which were characterized by NMR spectroscopy. The cytotoxic activities of 2a and 2b were evaluated against three human cancer cell lines, including A549 (lung), SKOV3 (ovary), and MCF-7 (breast). Our results indicated that 2a exhibited comparable cytotoxicity on inve

SUBMITTER: Faghih Z 

PROVIDER: S-EPMC7757979 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature