Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain.

ABSTRACT: The basal forebrain cholinergic system projects broadly throughout the cortex and constitutes a critical source of neuromodulation for arousal and attention. Traditionally, this system was thought to function diffusely. However, recent studies have revealed a high degree of spatiotemporal specificity in cholinergic signaling. How the organization of cholinergic afferents confers this level of precision remains unknown. Here, using intersectional genetic fate mapping, we demonstrate that cholinergic fibers within the mouse cortex exhibit remarkable laminar and regional specificity and that this is organized in accordance with cellular birthdate. Strikingly, birthdated cholinergic projections within the cortex follow an inside-out pattern of innervation. While early born cholinergic populati

SUBMITTER: Allaway KC 

PROVIDER: S-EPMC7758062 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature