A Novel Four-Gene Prognostic Signature as a Risk Biomarker in Cervical Cancer.

ABSTRACT:

Background

Cervical cancer (CC) is a major malignancy affecting women worldwide, with limited treatment options for patients with advanced disease. The aim of this study was to identify novel prognostic biomarkers for CC.

Methods

RNA-Seq data from four Gene Expression Omnibus datasets (GSE5787, GSE6791, GSE26511, and GSE63514) were used to identify differentially expressed genes (DEGs) between CC and normal cervical tissues. Functional and enrichment analyses of the DEGs were performed using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database and the Database for Annotation, Visualization, and Integrated Discovery (DAVID). The Oncomine database, Cytoscape software, and Kaplan-Meier survival analyses were used for in-depth screening of hub DEGs.

SUBMITTER: Wang J 

PROVIDER: S-EPMC7758149 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature