NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment.

ABSTRACT: Epidermal growth factor receptor (EGFR) is highly expressed in several types of cancer cells including oral squamous cell carcinoma (OSCC). EGF/EGFR signaling is recognized as an important molecular target in cancer therapy. However, cancer cells often become tolerant to EGF/EGFR signaling-targeted therapies. In the tumor microenvironment, the tumor incites inflammation and the inflammation-derived cytokines make a considerable impact on cancer development. In addition, hyperosmolarity is also induced, but the role of osmotic stress in cancer development has not been fully understood. This study demonstrates molecular insights into hyperosmolarity effect on OSCC development and shows that NFAT5 transcription factor plays an important functional role in enhancing the oral cancer cell prolif

SUBMITTER: Yoshimoto S 

PROVIDER: S-EPMC7758185 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature