Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System.

ABSTRACT: Ctip2/Bcl11b is a zinc finger transcription factor with dual action (repression/activation) that couples epigenetic regulation to gene transcription during the development of various tissues. It is involved in a variety of physiological responses under healthy and pathological conditions. Its role and mechanisms of action are best characterized in the immune and nervous systems. Furthermore, its implication in the development and homeostasis of other various tissues has also been reported. In the present review, we describe its role in skin development, adipogenesis, tooth formation and cranial suture ossification. Experimental data from several studies demonstrate the involvement of Bcl11b in the control of the balance between cell proliferation and differentiation during organ formation

SUBMITTER: Daher MT 

PROVIDER: S-EPMC7758212 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature