Expression and Prognostic Characteristics of m⁶ A RNA Methylation Regulators in Breast Cancer.

ABSTRACT:

Purpose

N6-methyladenosine (m⁶A) is the most prevalent modification in mRNA methylation which has a wide effect on biological functions. This study aims to figure out the efficacy of m⁶A RNA methylation regulator-based biomarkers with prognostic significance in breast cancer.

Patients and methods

The 23 RNA methylation regulators were firstly analyzed through ONCOMINE, then relative RNA-seq transcriptome and clinical data of 1,096 breast cancer samples and 112 normal tissue samples were acquired from The Cancer Gene Atlas (TCGA) database. The expressive distinction was also showed by the Gene Expression Omnibus (GEO) database. The gene expression data of m⁶A RNA regulators in human tissues were acquired from the Genotype-Tissue Expression (GT

SUBMITTER: Zhang B 

PROVIDER: S-EPMC7758326 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature