Genetic alterations associated with ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography in head and neck squamous cell carcinoma.

ABSTRACT:

Background

We investigated the relationship between genetic alterations and ¹⁸F-FDG PET/CT findings in head and neck squamous cell carcinoma (HNSC).

Methods

Using mRNA-sequences of HNSC samples (480 patients) from the Cancer Genome Atlas (TCGA) portal, gene coexpression networks were constructed via a weighted correlation network analysis (WGCNA) algorithm, and their association with the tumor-to-blood signal ratio on ¹⁸F-FDG PET/CT data (21 patients) was explored. An elastic-net regression model was developed to estimate the PET tumor-to-blood ratio from the gene networks and to derive an FDG signature score (FDG_SS). The FDG_SS was evaluated with regard to clinical variables and general mutational profiles, as well as alterations t

SUBMITTER: Han S 

PROVIDER: S-EPMC7758372 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature