Identification of Novel MeCP2 Cancer-Associated Target Genes and Post-Translational Modifications.

ABSTRACT: Abnormal regulation of DNA methylation and its readers has been associated with a wide range of cellular dysfunction. Disruption of the normal function of DNA methylation readers contributes to cancer progression, neurodevelopmental disorders, autoimmune disease and other pathologies. One reader of DNA methylation known to be especially important is MeCP2. It acts a bridge and connects DNA methylation with histone modifications and regulates many gene targets contributing to various diseases; however, much remains unknown about how it contributes to cancer malignancy. We and others previously described novel MeCP2 post-translational regulation. We set out to test the hypothesis that MeCP2 would regulate novel genes linked with tumorigenesis and that MeCP2 is subject to additional post-tran

SUBMITTER: Castro-Piedras I 

PROVIDER: S-EPMC7758440 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature