Transfer Function Models for the Localization of Seizure Onset Zone From Cortico-Cortical Evoked Potentials.

ABSTRACT: Surgical resection of the seizure onset zone (SOZ) could potentially lead to seizure-freedom in medically refractory epilepsy patients. However, localizing the SOZ can be a time consuming and tedious process involving visual inspection of intracranial electroencephalographic (iEEG) recordings captured during passive patient monitoring. Cortical stimulation is currently performed on patients undergoing invasive EEG monitoring for the main purpose of mapping functional brain networks such as language and motor networks. We hypothesized that evoked responses from single pulse electrical stimulation (SPES) can also be used to localize the SOZ as they may express the natural frequencies and connectivity of the iEEG network. To test our hypothesis, we constructed patient specific transfer functi

SUBMITTER: Kamali G 

PROVIDER: S-EPMC7758451 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature