CNS macrophages differentially rely on an intronic <i>Csf1r</i> enhancer for their development.

ABSTRACT: The central nervous system hosts parenchymal macrophages, known as microglia, and non-parenchymal macrophages, collectively termed border-associated macrophages (BAMs). Microglia, but not BAMs, were reported to be absent in mice lacking a conserved Csf1r enhancer: the fms-intronic regulatory element (FIRE). However, it is unknown whether FIRE deficiency also impacts BAM arrival and/or maintenance. Here, we show that macrophages in the ventricular system of the brain, including Kolmer's epiplexus macrophages, are absent in Csf1r^{ΔFIRE/ΔFIRE} mice. Stromal choroid plexus BAMs are also considerably reduced. During normal development, we demonstrate that intracerebroventricular macrophages arrive from embryonic day 10.5, and can traverse ventricular walls i

SUBMITTER: Munro DAD 

PROVIDER: S-EPMC7758622 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature