Association of Improved Periconception Hemoglobin A1c With Pregnancy Outcomes in Women With Diabetes.

ABSTRACT:

Importance

Prepregnancy diabetes is associated with higher perinatal and maternal morbidity, especially if periconception glycemic control is suboptimal. It is not known whether improved glycemic control from preconception to early pregnancy and midpregnancy periods can reduce the risk of adverse perinatal and maternal outcomes.

Objective

To determine whether a net decline in glycated hemoglobin A1c (HbA1c) from preconception to the first half of pregnancy is associated with a lower risk of adverse outcomes for mother and child.

Design, setting, and participants

This population-based cohort study was completed in all of Ontario, Canada, from 2007 to 2018. Included were births among women with prepregnancy diabetes whose HbA1c was measured within 90 days preconception

SUBMITTER: Davidson AJF 

PROVIDER: S-EPMC7758806 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature