Characterization of Retinal Microvascular and Choroidal Structural Changes in Parkinson Disease.

ABSTRACT:

Importance

Noninvasive retinal imaging may detect structural changes associated with Parkinson disease (PD) and may represent a novel biomarker for disease detection.

Objective

To characterize alterations in the structure and microvasculature of the retina and choroid in eyes of individuals with PD and compare them with eyes of age- and sex-matched cognitively healthy control individuals using optical coherence tomography (OCT) and OCT angiography (OCTA).

Design, setting, and participants

This cross-sectional study was conducted at the Duke Neurological Disorders Clinic in Durham, North Carolina. Individuals aged 50 years or older with a diagnosis of PD were eligible for inclusion and underwent an evaluation and diagnosis confirmation before enrollment. Control indivi

SUBMITTER: Robbins CB 

PROVIDER: S-EPMC7758829 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature