Association of the V122I Transthyretin Amyloidosis Genetic Variant With Cardiac Structure and Function in Middle-aged Black Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study.

ABSTRACT:

Importance

The variant V122I is commonly enriched in the transthyretin (TTR) gene in individuals of African ancestry and associated with greater risk of heart failure (HF) in older adulthood, after age 65 years. Prevention of HF may be most effective earlier in life, but whether screening with echocardiography can identify subclinical cardiac abnormalities during middle age to risk-stratify individuals appears to be unknown.

Objective

To examine the association between the V122I TTR variant and cardiac structure and function during middle age in those without prevalent HF.

Design, setting, and participants

This serial cross-sectional study of 875 Black participants in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort was conducted at 4 urban sites a

SUBMITTER: Sinha A 

PROVIDER: S-EPMC7758832 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature