Efficacy of Pazopanib With or Without Gemcitabine in Patients With Anthracycline- and/or Ifosfamide-Refractory Soft Tissue Sarcoma: Final Results of the PAPAGEMO Phase 2 Randomized Clinical Trial.

ABSTRACT:

Importance

Pazopanib and gemcitabine have shown good tolerability, albeit modest single-agent activity in pretreated soft tissue sarcoma. A combined regimen to improve outcomes is required.

Objective

To determine the efficacy of gemcitabine and pazopanib compared with pazopanib alone.

Design, setting, and participants

This multicenter, randomized phase 2 clinical trial was conducted in Germany from September 2011 to July 2014 and included patients with an Eastern Cooperative Oncology Group performance status score of 0 to 2, adequate organ function, measurable lesion, and progression after at least 1 prior treatment with anthracyclines and/or ifosfamide. Data analysis was performed during 2019 and 2020.

Interventions

Patients were randomized to pazopanib with g

SUBMITTER: Schmoll HJ 

PROVIDER: S-EPMC7758834 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature