Low intratumor heterogeneity correlates with increased response to PD-1 blockade in renal cell carcinoma.

ABSTRACT:

Background

Intratumor heterogeneity (ITH) has been shown to be inversely associated with immune infiltration in several cancers including clear cell renal cell carcinoma (ccRCC), but it remains unclear whether ITH is associated with response to immunotherapy (e.g. PD-1 blockade) in ccRCC.

Methods

We quantified ITH using mutant-allele tumor heterogeneity, investigated the association of ITH with immune parameters in patients with ccRCC (n = 336) as well as those with papillary RCC (pRCC, n = 280) from The Cancer Genome Atlas, and validations were conducted in patients with ccRCC from an independent cohort (n = 152). The relationship between ITH and response to anti-PD-1 immunotherapy was explored in patients with metastatic ccRCC from a clinical trial of

SUBMITTER: Ran X 

PROVIDER: S-EPMC7758866 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature