Facile Preparation of Tilmicosin-Loaded Polymeric Nanoparticle with Controlled Properties and Functions.

ABSTRACT: As one of the effective broad-spectrum antimicrobial and anti-inflammatory drugs, tilmicosin (TIM) is applied extensively in a wide range of veterinary treatments. However, the low bioavailability typically leads to overuse of TIM in practical applications, which can cause residual accumulation in the environment and contamination of foodstuffs. Here, we report a precipitation method that allows us to prepare TIM-loaded poly(methyl methacrylate-co-methacrylic acid) (P(MMA-co-MAA)) nanoparticles. Specifically, TIM and biocompatible P(MMA-co-MAA) are dissolved in methanol and then water is introduced as an antisolvent, which triggers the co-precipitation and leads to well-controlled nanoparticles. Depending on the drug/polymer mass ratio and the total concentration of dr

SUBMITTER: Yu J 

PROVIDER: S-EPMC7758884 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature