Prevalence of pretreatment HIV drug resistance in key populations: a systematic review and meta-analysis.

ABSTRACT:

Introduction

WHO's 2019 report on HIV drug resistance (HIVDR) documents a high prevalence of pretreatment drug resistance (PDR) among populations initiating first-line antiretroviral therapy (ART) in low- and middle-income countries (LMIC). However, systematic evidence on the prevalence of PDR among key populations remains limited. We performed a systematic review to characterize levels of PDR in key population groups and compared them to levels of PDR in the "general population" across different geographical regions.

Methods

Ten electronic databases were searched for papers published until February 2019 that included predefined search terms. We included studies that reported the number of successfully tested genotypes and the number of genotypes with drug resistance mutatio

SUBMITTER: Macdonald V 

PROVIDER: S-EPMC7758978 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature