Management of Stage IIB Cervical Cancer: an Overview of the Current Evidence.

ABSTRACT:

Purpose of review

To review and discuss the present evidence of surgery- and radiation-based treatment strategies for stage IIB cervical cancer.

Recent findings

Recently, two randomized controlled trials compared the efficacy of neoadjuvant chemotherapy followed by radical hysterectomy (NACT + RH) with that of concurrent chemoradiotherapy (CCRT) for stage IB3-IIB cervical cancer. When these studies were combined (N = 1259), NACT + RH was associated with a shorter disease-free survival [hazard ratio (HR) 1.36, 95% confidence interval (CI) 1.13-1.64], but with a similar overall survival (HR 1.11, 95% CI 0.90-1.36) when compared with the findings for CCRT. Stage-specific analysis for stage IIB cervical cancer demonstrated that disease-free survival was significantly worse with

SUBMITTER: Matsuzaki S 

PROVIDER: S-EPMC7759090 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature