A methodology for examining the association between plasma volume and micronutrient biomarker mass and concentration in healthy eumenorrheic women.

ABSTRACT:

Background

Accurate estimation and interpretation of nutritional biomarker concentrations are important in nutritional research, clinical care, and public health surveillance. Plasma volume (PV) may affect the interpretation of plasma biomarkers but is rarely measured. We aimed to examine the association between plasma volume (PV) and micronutrient biomarker concentrations and mass as part of pilot work to develop methods.

Methods

Nine healthy women with regular menstrual cycles provided fasting blood samples to measure micronutrient biomarkers. Indocyanine green was injected, and five timed blood draws were taken from 2 to 5 min to measure PV. Visits were scheduled around menstrual cycle day 2. Retinol, 25-hydroxyvitamin D, riboflavin, alpha-tocopherol, zinc, copper, magnes

SUBMITTER: Aguree S 

PROVIDER: S-EPMC7759127 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature