Pharmacokinetic interaction study between ligustrazine and valsartan in rats and its potential mechanism.

ABSTRACT:

Context

Ligustrazine and valsartan are commonly used drugs in the treatment of cardiac and cardiovascular disease.

Objective

The interaction between ligustrazine and valsartan was studied to investigate the effect of ligustrazine on the pharmacokinetics of valsartan.

Materials and methods

The pharmacokinetics of valsartan (10 mg/kg) was investigated in Sprague-Dawley rats divided into three groups (with the pretreatment of 4 or 10 mg/kg/day ligustrazine for 10 days and without the pretreatment of ligustrazine as control) of six rats each. The in vitro experiments in rat liver microsomes were performed to explore the effect of ligustrazine on the metabolic stability of valsartan.

Results

Ligustrazine changed the pharmacokinetic profile of valsartan. In th

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7759250 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature