Identification and validation of poor prognosis immunoevasive subtype of muscle-invasive bladder cancer with tumor-infiltrating podoplanin⁺ cell abundance.

ABSTRACT: The choice of chemo- or immuno-therapy for muscle-invasive bladder cancer (MIBC) patients remains contentious. Podoplanin is newly identified as an immune checkpoint which intrigues us to explore the clinical significance and immunoregulatory role of tumor-infiltrating podoplanin⁺ cells (PDPN⁺ cells) in MIBC. A retrospective analysis of 259 MIBC patients from Zhongshan Hospital (n = 141) and Shanghai Cancer Center (n = 118) was conducted. A total of 406 MIBC patients from TCGA database were enrolled to investigate the relationship between PDPN and molecular characterization. We found that tumor-infiltrating PDPN⁺ cell abundance indicated an inferior overall survival and recurrence-free survival. pT2 MIBC patients with PDPN⁺ cell low infiltration

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC7759386 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature