IgE and IgG Antibodies as Regulators of Mast Cell and Basophil Functions in Food Allergy.

ABSTRACT: Food allergy is a major health issue, affecting the lives of 8% of U.S. children and their families. There is an urgent need to identify the environmental and endogenous signals that induce and sustain allergic responses to ingested allergens. Acute reactions to foods are triggered by the activation of mast cells and basophils, both of which release inflammatory mediators that lead to a range of clinical manifestations, including gastrointestinal, cutaneous, and respiratory reactions as well as systemic anaphylaxis. Both of these innate effector cell types express the high affinity IgE receptor, FcϵRI, on their surface and are armed for adaptive antigen recognition by very-tightly bound IgE antibodies which, when cross-linked by polyvalent allergen, trigger degranulation. These cells also

SUBMITTER: Kanagaratham C 

PROVIDER: S-EPMC7759531 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature