Nanomedicine for Acute Brain Injuries: Insight from Decades of Cancer Nanomedicine.

ABSTRACT: Acute brain injuries such as traumatic brain injury and stroke affect 85 million people a year worldwide, and many survivors suffer from long-term physical, cognitive, or psychosocial impairments. There are few FDA-approved therapies that are effective at preventing, halting, or ameliorating the state of disease in the brain after acute brain injury. To address this unmet need, one potential strategy is to leverage the unique physical and biological properties of nanomaterials. Decades of cancer nanomedicine research can serve as a blueprint for innovation in brain injury nanomedicines, both to emulate the successes and also to avoid potential pitfalls. In this review, we discuss how shared disease physiology between cancer and acute brain injuries can inform the design of novel nanomedici

SUBMITTER: Kandell RM 

PROVIDER: S-EPMC7759589 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature