Multi-Omics Analysis of Diabetic Nephropathy Reveals Potential New Mechanisms and Drug Targets.

ABSTRACT: Diabetic nephropathy (DN) is one of the most common diabetic complications, which is the major course of end-stage renal disease (ESRD). However, the systematical molecular characterizations during DN pathogenesis and progression has not been not well understood. To identify the fundamental mediators of the pathogenesis and progression of DN. we performed a combination RNASeq, proteomics, and metabolomics analyses of both patients' derived kidney biopsy samples and kidneys from in vivo DN model. As a result, molecular changes of DN contain extracellular matrix accumulation, abnormal activated inflamed microenvironment, and metabolism disorders, bringing about glomerular sclerosis and tubular interstitial fibrosis. Specificity, Further integration analyses have identified that the li

SUBMITTER: Sha Q 

PROVIDER: S-EPMC7759603 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature