The Olfactory Bulb Facilitates Use of Category Bounds for Classification of Odorants in Different Intensity Groups.

ABSTRACT: Signal processing of odor inputs to the olfactory bulb (OB) changes through top-down modulation whose shaping of neural rhythms in response to changes in stimulus intensity is not understood. Here we asked whether the representation of a high vs. low intensity odorant in the OB by oscillatory neural activity changed as the animal learned to discriminate odorant concentration ranges in a go-no go task. We trained mice to discriminate between high vs. low concentration odorants by learning to lick to the rewarded group (low or high). We recorded the local field potential (LFP) in the OB of these mice and calculated the theta-referenced beta or gamma oscillation power (theta phase-referenced power, or tPRP). We found that as the mouse learned to differentiate odorant concentrations, tPRP dive

SUBMITTER: Losacco J 

PROVIDER: S-EPMC7759615 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature