Glioblastoma Distance From the Subventricular Neural Stem Cell Niche Does Not Correlate With Survival.

ABSTRACT:

Objective

To determine the relationship between survival and glioblastoma distance from the ventricular-subventricular neural stem cell niche (VSVZ).

Methods

502 pre-operative gadolinium-enhanced, T1-weighted MRIs with glioblastoma retrieved from an institutional dataset (n = 252) and The Cancer Imaging Atlas (n=250) were independently reviewed. The shortest distance from the tumor contrast enhancement to the nearest lateral ventricular wall, the location of the VSVZ, was measured (GBM-VSVZ_Dist). The relationship of GBM-VSVZ_Dist with the proportion of glioblastomas at each distance point and overall survival was explored with a Pearson's correlation and Cox regression model, respectively, adjusting for the well-established glioblastoma prognosticators.<

SUBMITTER: Mistry AM 

PROVIDER: S-EPMC7759619 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature