Intestinal Transcriptome Analysis Reveals Soy Derivative-Linked Changes in Atlantic Salmon.

ABSTRACT: Intestinal inflammation in farmed fish is a non-infectious disease that deserves attention because it is a major issue linked to carnivorous fishes. The current norm is to formulate feeds based on plant-derived substances, and the ingredients that have antinutritional factors are known to cause intestinal inflammation in fishes such as Atlantic salmon. Hence, we studied inflammatory responses in the distal intestine of Atlantic salmon that received a feed rich in soybean derivatives, employing histology, transcriptomic and flow cytometry techniques. The fish fed on soy products had altered intestinal morphology as well as upregulated inflammation-associated genes and aberrated ion transport-linked genes. The enriched pathways for the upregulated genes were among others taurine and hypotaur

SUBMITTER: Kiron V 

PROVIDER: S-EPMC7759687 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature