A Continuous Cell Separation and Collection Approach on a Microfilter and Negative Dielectrophoresis Combined Chip.

ABSTRACT: Cell separation plays an important role in the fields of analytical chemistry and biomedicine. To solve the blockage problem and improve the separation throughput in the traditional microstructure filtration-based separation approach, a continuous cell separation and collection approach via micropost array railing on a microfilter and negative dielectrophoresis combined chip is proposed. By tilting the micropost array at a certain angle, microparticles or cells enter the collection area under micropost array railing. The effects of the inclination angle of the micropost array and the electrode distance on the microparticle collection efficiency were investigated. Based on the optimized microfluidic chip structure, 37- and 16.3-μm particles were collected with 85% and 89% efficiencies, resp

SUBMITTER: Wang Q 

PROVIDER: S-EPMC7759882 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature