Hsa-miR-375/RASD1 Signaling May Predict Local Control in Early Breast Cancer.

ABSTRACT: In order to characterize the various subtypes of breast cancer more precisely and improve patients selection for breast conserving therapy (BCT), molecular profiling has gained importance over the past two decades. MicroRNAs, which are small non-coding RNAs, can potentially regulate numerous downstream target molecules and thereby interfere in carcinogenesis and treatment response via multiple pathways. The aim of the current two-phase study was to investigate whether hsa-miR-375-signaling through RASD1 could predict local control (LC) in early breast cancer. The patient and treatment characteristics of 81 individuals were similarly distributed between relapse (n = 27) and control groups (n = 54). In the pilot phase, the primary tumors of 28 patients were analyzed with microarray technolog

SUBMITTER: Zellinger B 

PROVIDER: S-EPMC7759924 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature