Epidemiology and Sequence-Based Evolutionary Analysis of Circulating Non-Polio Enteroviruses.

ABSTRACT: Enteroviruses (EVs) are positive-sense RNA viruses, with over 50,000 nucleotide sequences publicly available. While most human infections are typically associated with mild respiratory symptoms, several different EV types have also been associated with severe human disease, especially acute flaccid paralysis (AFP), particularly with endemic members of the EV-B species and two pandemic types-EV-A71 and EV-D68-that appear to be responsible for recent widespread outbreaks. Here we review the recent literature on the prevalence, characteristics, and circulation dynamics of different enterovirus types and combine this with an analysis of the sequence coverage of different EV types in public databases (e.g., the Virus Pathogen Resource). This evaluation reveals temporal and geographic difference

SUBMITTER: Brown DM 

PROVIDER: S-EPMC7759938 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature